Digestive diseases account for 13% of all deaths in the UK, with one particular area of concern being paediatric constipation; approximately 10% of children suffer with constipation at some point in their lives. Current treatment is based mostly on reported symptoms with the use of harmful X-ray methods to measure gut transit time, which isn’t very accurate. Dr Luca Marciani, Associate Professor in Gastrointestinal Magnetic Resonance Imaging (GI MRI) at Nottingham University Hospitals NHS Foundation Trust (NUH) and his team were awarded an NIHR i4i grant to address this problem. Their current trial, MAGIC2 (MAGnetic resonance Imaging of gastrointestinal transit in paediatric Constipation 2), builds on their previous MAGIC trial to develop easy to swallow mini capsules that can be detected and analysed using an MRI scan, which are non-invasive and not harmful to the body. MAGIC2 is a multi-centre randomised control trial.
NIHR CYP MedTech are supporting the MAGIC2 trial by identifying clinical experts and sites for the study as well as disseminating project results and working on NHS adoption of the device when the trail is closer to completion.
The study team has worked closely with NUH’s Young Persons Advisory Group (YPAG), scientists, and members of industry to ensure that the mini capsules are fit for purpose, meets the needs of children and young people, and will provide clinicians with a great deal more opportunity to analyse colon activity when compared with current clinical practice.